Gene information
Official symbol COL1A2
Official full name collagen type I alpha 2 chain
Gene type protein-coding gene
Chromosome7q21.3
Previous symbolOI4
Gene familyCollagens
Resources
Entrez Gene 1278
HGNC HGNC:2198
Ensembl ENSG00000164692
Vega OTTHUMG00000148675
UCSC uc003ung.1
GO terms: 49 records
GO Description Category LogP Number of genes Detail
GO:0001101 response to acid chemical GO Biological Processes -10.2965313 26 More
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005198 structural molecule activity GO Molecular Functions -7.51921139 30 More
GO:0005201 extracellular matrix structural constituent GO Molecular Functions -12.8379048 20 More
GO:0005581 collagen trimer GO Cellular Components -6.28484906 16 More
GO:0005583 fibrillar collagen trimer GO Cellular Components -3.34912948 3 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -8.77828157 29 More
GO:0007179 transforming growth factor beta receptor signaling pathway GO Biological Processes -7.95704539 19 More
GO:0007264 small GTPase mediated signal transduction GO Biological Processes -2.76738893 22 More
GO:0007265 Ras protein signal transduction GO Biological Processes -1.87357952 15 More
GO:0007266 Rho protein signal transduction GO Biological Processes -1.86130079 7 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0030020 extracellular matrix structural constituent conferring tensile strength GO Molecular Functions -4.38480829 9 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030199 collagen fibril organization GO Biological Processes -7.34609657 9 More
GO:0030282 bone mineralization GO Biological Processes -8.89624301 10 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031214 biomineral tissue development GO Biological Processes -8.35916144 12 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043200 response to amino acid GO Biological Processes -9.16129691 23 More
GO:0043588 skin development GO Biological Processes -3.97728448 25 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0046332 SMAD binding GO Molecular Functions -2.44266926 5 More
GO:0048407 platelet-derived growth factor binding GO Molecular Functions -5.05315969 4 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071229 cellular response to acid chemical GO Biological Processes -7.57719972 18 More
GO:0071230 cellular response to amino acid stimulus GO Biological Processes -6.04975320 15 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0097435 supramolecular fiber organization GO Biological Processes -6.48496756 24 More
GO:0098643 banded collagen fibril GO Cellular Components -3.34912948 3 More
GO:0098644 complex of collagen trimers GO Cellular Components -3.64344566 6 More
GO:0110148 biomineralization GO Biological Processes -9.16361193 13 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04974 Protein digestion and absorption KEGG Pathway -4.19153592 8 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
Drug-Gene interaction
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Related drugs: 2 records
Related studies: 9 records
Molecular factor Omics type Application Objective MI type Reference
procollagen type I C-terminal peptide proteomics poor predictor left ventricular remodeling[prognosis (bad)] acute myocardial infarction Murakami T et al. Clin Chem. 1998
procollagen type I C-terminal peptide proteomics left ventricular remodeling[prognosis (bad)] myocardial infarction Takino T et al. Cardiology. 1999
procollagen type I C-terminal peptide proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Poulsen SH et al. Cardiology. 2001
procollagen type I C-terminal peptide proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Poulsen SH et al. Cardiology. 2001
procollagen type I C-terminal peptide proteomics coronary revascularization[prognosis (bad)] acute ST elevation myocardial infarction Ren HZ et al. Heart Lung. 2012
procollagen type I N-terminal peptide proteomics ventricular tachycardia[prognosis (bad)] old myocardial infarction Blangy H et al. Europace. 2007
procollagen type I N-terminal peptide proteomics death[prognosis (bad)] acute myocardial infarction Manhenke C et al. Int J Cardiol. 2011
procollagen type I N-terminal peptide proteomics myocardial infarction[diagnosis] myocardial infarction Yeap BB et al. J Clin Endocrinol Metab. 2015
type I collagen proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Bertelsen DM et al. Sci Rep. 2018
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